1. Signaling Pathways
  2. Neuronal Signaling
  3. AChE


Acetylcholinesterase (AChE or acetylhydrolase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs tocarboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules ofacetylcholine (ACh) per second, approaching the limit allowed by diffusion of the substrate. ACh is released from the nerve into the synaptic cleft and binds to ACh receptors on the post-synaptic membrane, relaying the signal from the nerve. AChE, also located on the post-synaptic membrane, terminates the signal transmission by hydrolyzing ACh. The liberated choline is taken up again by the pre-synaptic nerve and ACh is synthetized by combining with acetyl-CoA through the action of choline acetyltransferase.

AChE 相关产品 (40):

Cat. No. Product Name Effect Purity
  • HY-76299
    Galanthamine Inhibitor 99.90%
    Galanthamine 是一种有效的乙酰胆碱酯酶 (AChE) 抑制剂,IC50 为 500 nM。
  • HY-B0034
    Donepezil Hydrochloride Inhibitor 99.97%
    Donepezil(E 2020)盐酸盐是非竞争性的AChE抑制剂,能穿过血脑屏障,增加皮质中的乙酰胆碱水平。
  • HY-B0943
    Malathion Inhibitor >98.0%
  • HY-17552
    sn-Glycero-3-phosphocholine Activator >98.0%
    L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate)是存在于脑和奶中的天然胆碱化合物,也是拟副交感神经乙酰胆碱前体。
  • HY-17368
    Rivastigmine Inhibitor 99.39%
    Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
  • HY-114320
    BuChE-IN-TM-10 Inhibitor
    BuChE-IN-TM-10 (TM-10)是一种有效的丁基胆碱酯酶 (BuChE) 抑制剂,其IC50 值为8.9 nM。BuChE inhibitor 1能够抑制和分解自诱导的Aβ聚合, 表现出强大的抗氧化活性和良好的血脑屏障 (BBB) 渗透性。有治疗阿尔兹海默症的潜能。
  • HY-N0226
    Epiberberine Inhibitor
    Epiberberine 是从黄连中得到的生物碱,为有效的 AChEBChE 抑制剂,和非竞争性的 BACE1 抑制剂,IC50 值分别为 1.07,6.03 和 8.55 μM。Epiberberine 具有抗氧化作用,能够清除 ONOO- (IC50,16.83 μM),对阿尔滋海默症和糖尿病有潜在治疗作用。在 3T3-L1 细胞分化早期,Epiberberine 能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。
  • HY-B1626A
    Demecarium Bromide Inhibitor
    Demecarium Bromide (BC-48) 是一种有效的 cholinesterase 抑制剂,Kiapp 值为 0.15 μM。Demecarium Bromide (BC-48) 用作青光眼治疗剂。
  • HY-17388
    (±)-Huperzine A Inhibitor >98.0%
    Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
  • HY-B0942
    Benzethonium chloride Inhibitor >98.0%
    Benzethonium chloride作用于在爪蟾卵母细胞,抑制人重组α7和α4β2神经元烟碱性乙酰胆碱受体。
  • HY-B2244
    Tacrine hydrochloride hydrate Inhibitor 99.98%
    Tacrine hydrochloride hydrate 是乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 的抑制剂,其 IC50 值分别为 31 nM 和 25.6 nM。
  • HY-14566
    Donepezil Inhibitor 99.87%
    Donepezil(E 2020)是AChE抑制剂,对bAChE和hAChE的IC50分别为8.12 nM和11.6 nM。
  • HY-A0009
    Galanthamine hydrobromide Inhibitor 99.93%
    Galanthamine氢溴酸盐是长效的中心活性的乙酰胆碱酯酶(AChE)抑制剂,IC50为410 nM,同时是神经元烟碱乙酰胆碱受体的变构增强剂。
  • HY-N0342
    Scopoletin Inhibitor 99.57%
    Scopoletin 是一种乙酰胆碱酯酶 (AChE) 抑制剂。
  • HY-17387
    (-)-Huperzine A Inhibitor >98.0%
    Huperzine A是传统中草药中提取的活性石松属生物碱,是可逆的乙酰胆碱酯酶(ACE)抑制剂,在中国被广泛的运用于阿尔茨海默病。
  • HY-B0949
    Protriptyline hydrochloride Inhibitor 99.91%
  • HY-B0207A
    Pyridostigmine bromide Inhibitor >98.0%
  • HY-N0285
    Imperatorin Inhibitor 98.11%
    Imperatorin 是一种有效的 NO synthesis 抑制剂,IC50 为 9.2 μmol,也是 BChE 抑制剂,IC50 为 31.4 μmol。Imperatorin 是 TRPV1 的微弱激动剂,EC50 为 12.6±3.2 μM。
  • HY-11017
    Rivastigmine tartrate Inhibitor 98.53%
    Rivastigmine酒石酸盐是胆碱酯酶抑制剂,IC50为5.5 uM,还能抑制丁酰胆碱酯酶和乙酰胆碱酯酶。
  • HY-N0226A
    Epiberberine chloride Inhibitor 99.60%
    Epiberberine chloride 是从黄连中得到的生物碱,为有效的 AChEBChE 抑制剂,和非竞争性的 BACE1 抑制剂,IC50 值分别为 1.07,6.03 和 8.55 μM。Epiberberine chloride 具有抗氧化作用,能够清除 ONOO- (IC50,16.83 μM),对阿尔滋海默症和糖尿病有潜在治疗作用。在 3T3-L1 细胞分化早期,Epiberberine chloride 能够下调 Raf/MEK1/2/ERK1/2 和 AMPKα/Akt 信号通路。
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