1. Metabolic Enzyme/Protease
  2. Acetyl-CoA Carboxylase

Acetyl-CoA Carboxylase

Acetyl-CoA carboxylase (ACC) is a biotin carboxylase that catalyzes the ATP-dependent condensation of acetyl-CoA and carbonate to form malonyl-CoA。 The malonyl-CoA produced by ACC serves two major physiologic functions。 It is an essential and rate-limiting substrate for de novo lipogenesis (DNL), and it acts as an allosteric inhibitor of the enzyme carnitine-palmitoyl transferase I (CPT-1)。 Acetyl-CoA carboxylase (ACC) inhibitors offer significant potential for the treatment of type 2 diabetes mellitus (T2DM), hepatic steatosis, and cancer。

Acetyl-CoA carboxylase (ACC) in mammals is encoded by two related enzymes ACC1 and ACC2, which catalyze the ATP dependent carboxylation of acetyl-CoA to form malonyl-CoA. ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn, whereas ACC2 is tethered to the mitochondrial outer membrane, where localized malonyl-CoA production blocks CPT-1 function to prevent fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn).

Acetyl-CoA Carboxylase 相关产品 (8):

Cat. No. Product Name Effect Purity
  • HY-16901
    Firsocostat Inhibitor 98.72%
    Firsocostat (ND-630; GS-0976; NDI-010976) 是乙酰辅酶A羧化酶 (ACC) 抑制剂,抑制人类 ACC1 和 ACC2 的 IC50 值分别为2.1和6.1 nM。
  • HY-101842
    ND-646 Inhibitor 98.39%
    ND-646 是一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂,抑制重组 hACC1 和 hACC2,IC50 分别为 3.5 nM 和 4.1 nM。
  • HY-101068
    TOFA Inhibitor >98.0%
    TOFA (RMI14514;MDL14514)是乙酰辅酶A羧化酶-α (ACCA )的变构抑制剂。
  • HY-15259A
    CP-640186 hydrochloride Inhibitor 99.40%
    CP-640186 hydrochloride是一种有效且可透过细胞的乙酰辅酶A羧化酶 (ACC)抑制剂,抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的 IC50为53 nM和61 nM。
  • HY-12942
    PF-05175157 Inhibitor 98.74%
    PF-05175157 是一种广谱乙酰辅酶 A 羧化酶 (ACC) 抑制剂,对 ACC1 (human),ACC2 (human), ACC1 (rat) 和 ACC2 (rat) 的 IC50 值分别为 27.0, 33.0, 23.5 和 50.4 nM。
  • HY-17641
    Olumacostat glasaretil Inhibitor 98.78%
    Olumacostat glasaretil是乙酰辅酶A羧化酶(ACC)的小分子抑制剂。
  • HY-107709
    MK-4074 Inhibitor 98.72%
    MK-4074是乙酰辅酶A羧化酶 (acetyl-CoA carboxylase) 的肝特异性抑制剂,IC50 值约为3nM。
  • HY-15259
    CP-640186 Inhibitor
    CP-640186是乙酰辅酶A羧化酶(ACCase)抑制剂,对鼠肝ACCase1和骨骼肌ACCase2的IC50s分别为53 nM和61 nM,比CP-610431有更好的代谢稳定性。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

江苏快三 江苏快三 江苏快3 江苏快3 江苏快三 江苏快三 江苏快三 江苏快三 江苏快3 江苏快三