1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)

Angiotensin-converting Enzyme (ACE)

Angiotensin-converting enzyme (ACE) indirectly increases blood pressure by causing blood vessels to constrict. ACE does that by converting angiotensin I to angiotensin II, which constricts the vessels. ACE, angiotensin I and angiotensin II are part of the renin-angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body. ACE is secreted in the lungs and kidneys by cells in the endothelium (inner layer) of blood vessels. It has two primary functions: ACE catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in a substrate concentration-dependent manner. ACE degrades bradykinin, a potent vasodilator, and other vasoactive peptides. These two actions make ACE inhibition a goal in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy, and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in the decreased formation of angiotensin II and decreased metabolism of bradykinin, leading to systematic dilation of the arteries and veins and a decrease in arterial blood pressure.

Angiotensin-converting Enzyme (ACE) 相关产品 (39):

Cat. No. Product Name Effect Purity
  • HY-12403
    Angiotensin 1-7 Inhibitor 99.61%
    Angiotensin (1-7) 抑制纯化的犬血管紧张素转换酶 (ACE) 活性,IC50 为 0.65 μM。
  • HY-B0368
    Captopril Inhibitor 98.05%
    Captopril (SQ-14534) 是血管紧张素转化酶(ACE)抑制剂。
  • HY-B0093A
    Benazepril hydrochloride Inhibitor 99.85%
  • HY-B0331A
    Enalapril maleate Inhibitor 99.96%
    Enalapril (maleate) (MK-421 (maleate)) 是 Enalapril 的活性代谢物,是血管紧张素转化酶(ACE)抑制剂。
  • HY-N2021A
    Phosphoramidon Disodium Inhibitor >98.0%
    Phosphoramidon disodium 是金属蛋白酶 ( metalloprotease ) 抑制剂 。抑制内皮素转化酶 ( ECE ) ,中性肽内切酶 ( NEP ) 和血管紧张素转换酶 ( ACE ) 的IC50 值分别为 3.5 ,0.034 和 78 μM。
  • HY-106446
    Rentiapril Inhibitor
    Rentiapril 是一种具有口服活性的血管紧张素转换酶 (ACE) 抑制剂,具有抗高血压活性。
  • HY-W009732
    Sinapinic acid Inhibitor 99.61%
    Sinapinic acid (Sinapic acid) 是从 Hydnophytum formicarum Jack. 根中分离到的酚类化合物,为 HDAC 的抑制剂,IC50 值 2.27 mM,对 ACE-I 的活性也有抑制作用。Sinapinic acid 具有有效的抗肿瘤活性,诱导肿瘤细胞凋亡。Sinapinic acid 具有抗氧化、抗糖尿病的作用。Sinapinic acid 可以降低卵巢切除大鼠的总胆固醇、甘油三酯和 HOMA-IR 指数,并使抗氧化能力和氧化损伤的一些血清参数正常化。
  • HY-114424
    H-Ile-Pro-Pro-OH Inhibitor
    H-Ile-Pro-Pro-OH 是一种乳源三肽,抑制血管紧张素转换酶 (ACE) ,IC50 为 5 μM。具有抗高血压效果。
  • HY-B0130A
    Perindopril erbumine Inhibitor 99.33%
  • HY-B0382
    Fosinopril sodium Inhibitor >98.0%
  • HY-18206A
    Lisinopril dihydrate Inhibitor >98.0%
    Lisinopri (dihydrate) (lMK-521 (dihydrate)) 是血管紧张素转化酶抑制剂,可作用于高血压,充血性心力衰竭和心脏病等。
  • HY-B0592
    Trandolapril Inhibitor 98.01%
  • HY-B0279
    Ramipril Inhibitor 99.81%
    Ramipril (HOE-498) 是ACE抑制剂,IC50为5 nM。
  • HY-B0384
    Temocapril hydrochloride Inhibitor 99.52%
  • HY-B0231
    Enalaprilat dihydrate Inhibitor >99.0%
    Enalaprilat (dihydrate) (MK-422) 是血管紧张素转化酶 (ACE) 抑制剂,IC50 为 1.94 nM。
  • HY-B0477
    Quinapril hydrochloride Inhibitor 99.10%
    Quinapril (hydrochloride) (CI-906) 是血管紧张素转化酶 (ACE) 抑制剂的原药。
  • HY-18208
    Omapatrilat Inhibitor
    Omapatrilat是金属蛋白酶ACENEP的双重抑制剂,Ki值分别为0.64和0.45 nM。
  • HY-B1451
    Imidapril hydrochloride Inhibitor 99.95%
    Imidapril盐酸盐是血管紧张素转换酶 (ACE) 抑制剂,具有抗高血压活性。
  • HY-A0043A
    Cilazapril monohydrate Inhibitor 98.63%
  • HY-P0318
    Hemorphin-7 Inhibitor 99.65%
    Hemorphin-7 是一种血啡肽 (hemorphin),是来源于血红蛋白β链的一种内源性阿片类物质。Hemorphin 能够活化阿片类受体 (opioid receptor) 以及抑制血管紧张素转化酶 (angiotensin-converting enzyme),具有抗伤害、抗高血压的作用。
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