1. Signaling Pathways
  2. Protein Tyrosine Kinase/RTK
  3. Itk


Itk (Interleukin-2-inducible T-cell kinase) is a member of the TEC family of kinases and is highly expressed in T cells. Itk plays a role in T-cell proliferation, differentiation, cytokine release and chemotaxis. Itk is functionally important for the development and effector function of Th2 and Th17 cells. Itk is an attractive target for the treatment of T-cell-mediated inflammatory diseases.

Itk 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-11092
    BMS-509744 Inhibitor 98.02%
    BMS-509744是有效,选择性的 Itk 激酶抑制剂,IC50值为19 nM。
  • HY-12680
    PRN694 Inhibitor 99.44%
    PRN694 是一种高度选择且有效的 T 细胞激酶 (ITK) 和静息淋巴细胞激酶 (RLK) 的共价抑制剂,其 IC50 值分别为 0.3 和 1.4 nM。
  • HY-109078
    Vecabrutinib Inhibitor 99.96%
    Vecabrutinib 是一种有效的,非共价的 BTKITK 抑制剂,Kd 值分别为 0.3 nM 和 2.2 nM;Vecabrutinib 对 ITK 的 IC50 值为 24 nM。
  • HY-11066
    ITK inhibitor Inhibitor
  • HY-108691
    PF-06465469 Inhibitor
    PF-06465469 是 ITK 的共价抑制剂,IC50 值为 2 nM。
  • HY-16984
    GNE-4997 Inhibitor
    GNE-4997 是一种有效且有选择性的 ITK/TSK 抑制剂。
Isoform Specific Products

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