1. Immunology/Inflammation
  2. PGE synthase

PGE synthase

PGE synthase (Prostaglandin E synthase), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions。 Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90)。 Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family。 These two PGESs display distinct functional coupling with upstream COXs in cells; cPGES is predominantly coupled with the constitutive COX-1, whereas mPGES is preferentially linked with the inducible COX-2。 Several cytosolic GSTs also have the capacity to convert PGH2 to PGE2 in vitro。 Accumulating evidence has suggested that mPGES participates in various pathophysiological states in which COX-2 is involved, implying that mPGES represents a potential novel target for drug development。

PGE synthase 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-N0297
    Sinensetin Inhibitor 99.22%
    Sinensetin是一个能够在水果中发现的甲基化黄酮,有很强的抗血管和抗炎症的能力.
  • HY-B0890
    Zomepirac sodium salt Inhibitor 99.40%
    Zomepirac钠盐是一种前列腺素合成酶抑制剂。
  • HY-B0683
    Limaprost Agonist 99.76%
    Limaprost(OP1206)是PGE1类似物,是血小板粘附抑制剂。
  • HY-10582
    Flurbiprofen Inhibitor 99.85%
    Flurbiprofen是非甾体抗炎化合物,有退热止痛的效果。
  • HY-13283
    MF63 Inhibitor 98.94%
    MF63是mPGES-1抑制剂,对猪mPGES-1和人mPGES-1的IC50分别为0.9 nM和1.3 nM。
  • HY-B0550
    Bismuth Subsalicylate Inhibitor
    Bismuth Subsalicylate能抑制前列腺素G/H合酶1/2。
  • HY-12791
    hPGDS-IN-1 Inhibitor
    hPGDS-IN-1是一种hPGDS抑制剂, 荧光偏振检测或EIA法测得IC50值为12 nM。
  • HY-B0270
    Suprofen Inhibitor 99.44%
    Suprofen (TN-762) 是非甾体抗炎化合物,能抑制前列腺素合成。
  • HY-30235A
    Benzydamine hydrochloride Inhibitor 98.79%
    Benzydamine盐酸盐是前列腺素合成酶抑制剂,抗炎症,还报道有抗细菌活性。
  • HY-B0336
    Pranoprofen Inhibitor 98.48%
    Pranoprofen是非甾体抗炎化合物,可作用于眼科疾病。
  • HY-10439
    HPGDS inhibitor 1 Inhibitor 99.49%
    HPGDS inhibitor 1是造血前列腺素D合成酶(HPGDS)抑制剂,IC50为0.7 nM。
  • HY-101587
    PGS-IN-1 Inhibitor
    PGS-IN-1是有效的前列腺素合成酶 (prostaglandin synthetase) 抑制剂,IC50 值为0.28 μM;也可抑制5-脂肪氧合酶 (5-lipoxygenase) 的活性,IC50 值为 1.05 μM。
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