1. Signaling Pathways
  2. Vitamin D Related
  3. VD/VDR

VD/VDR

Vitamin D is a secosteroidalprohormone, it can be synthesized at sufficient levels in skin, given adequate skin exposure to UV B radiation from sunlight. Vitamin D modulates its biological effects by directly regulating target gene expression through the Vitamin D receptor (VDR), a ligand-regulated transcription factor and a member of the nuclear receptor superfamily. Whether synthesized in the skin or ingested, vitamin D requires two hydroxylation steps to become the biologically active hormone, 1,25-dyhydroxyvitamin D3 [1,25(OH)2D3], a form that signals through the VDR. The hormone-bound VDR modulates target gene transcription in response to vitamin D. VDR acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in breast cancer (BC) cells.

There are 2 forms of vitamin D. Vitamin D2 (ergocalciferol) comes from irradiation of the yeast and plant sterol ergosterol, and vitamin D3 (cholecalciferol) is found in oily fish and cod liver oil and is made in the skin. Vitamin D represents vitamin D2 and vitamin D3.

Topical agents containing active vitamin D3 (calcitriol, 1α, 25- dihydroxyvitaminD3, VD3) analogues such as Tacalcitol, Calcipotriol and Maxacalcitol are widely used for psoriasis therapy.

VD/VDR 相关产品 (55):

Cat. No. Product Name Effect Purity
  • HY-10002
    Calcitriol Agonist 99.81%
    Calcitriol 是活性最大的 vitamin D 代谢物,也是 vitamin D 受体 (VDR) 的激动剂。
  • HY-10001
    Calcipotriol Chemical 99.77%
    Calcipotriol 是一种合成的 VitD3 类似物,对 vitamin D 受体具有高亲和力。
  • HY-32339
    Maxacalcitol Activator 99.71%
    Maxacalcitol (22-Oxacalcitriol) 是非血钙维生素D3类似物和VDR样受体的配体。
  • HY-15398
    Cholecalciferol Activator >98.0%
    Cholecalciferol(Vitamin D3)是维生素D的天然存在形式,代谢激活后能诱导细胞分化和癌细胞增殖。
  • HY-50919
    Paricalcitol Agonist 99.95%
    Paricalcitol 是 vitamin D receptor 的激活剂,用于治疗继发性甲状旁腺功能亢进(分泌过多的甲状旁腺激素),该疾病与慢性肾功能衰竭有关。
  • HY-114310
    VDR agonist 1 Agonist
    VDR agonist 1 (compound 28) 是一种非甾体类维生素 D 受体 (VDR) 的激动剂, 在MCF-7 细胞中测得其 IC50 值为 690 nM。VDR agonist 1 通过上调 p21 和 p27 的表达来抑制细胞周期,通过增加 BAX 的表达来促进细胞凋亡,降低 Bcl-2 的表达。
  • HY-32351A
    Calcifediol monohydrate 99.89%
    Calcifediol monohydrate 是维生素 D3 的主要循环代谢物, 是一种竞争性抑制剂,Ki 值为 3.9 μM。
  • HY-32350
    Ercalcitriol Activator 99.33%
    Ercalcitriol (1α,25-Dihydroxy Vitamin D2)是维生素D2活性代谢物。
  • HY-32349
    Ercalcidiol Modulator 98.93%
    Ercalcidiol 是一种 vitamin D2 代谢物,作为 vitamin D 营养状态的指标。
  • HY-10001A
    Calcipotriol monohydrate Activator 99.75%
    Calcipotriol是1,25-Dihydroxyvitamin D3类似物,可作用于银屑病。
  • HY-15254
    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 Chemical 98.71%
    3-O-(2-Aminoethyl)-25-hydroxyvitamin D3 是一种Vitamin D3 衍生物。
  • HY-32341
    Seocalcitol Agonist 98.67%
    Seocalcitol 是一种 vitamin D 类似物,作用于人骨肉瘤 MG-63 细胞,结合 vitamin D 受体蛋白,Kd 为 0.27 nM。
  • HY-15157
    Calcitetrol Activator
    Calcitetrol(1α, 24, 25-Trihydroxy VD3)是含3个羟基的维生素D活性形式。
  • HY-32343
    Secalciferol Activator 98.58%
    Secalciferol是维生素D的代谢物,是潜在的参与骨化作用的抗炎甾体。
  • HY-10003
    Alfacalcidol Activator 99.93%
    Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3)是非选择性VDR活化剂。
  • HY-76542
    Vitamin D2 Activator >98.0%
    Vitamin D2 (Ergocalciferol)是维生素D的一种形式, 通过类固醇的光化学键断裂形成的, 可用作维生素D补充剂。
  • HY-15830
    25,26-Dihydroxyvitamin D3 Activator
    25,26-Dihydroxyvitamin D3是维生素D3代谢物。
  • HY-32348
    Doxercalciferol Activator 99.85%
    Doxercalciferol 是维生素 D2 类似物,为维生素 D (Vitamin D) 受体激活剂,能够抵抗肾病的进程。
  • HY-A0020
    Eldecalcitol Activator 99.95%
    Eldecalcitol (ED-71) 是1,25-二羟基维生素D3的类似物。
  • HY-76801
    24, 25-Dihydroxy VD2 Activator 99.79%
    24, 25-Dihydroxy VD2是维生素D2的羟基化代谢产物,是合成的维生素D类似物。
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