1. GSK319347A

GSK319347A (Synonyms: IKK-3 Inhibitor)

目录号: HY-14682 纯度: >98.0%
产品使用指南

GSK319347A 是 TBK1IKKε 的双重抑制剂,IC50 分别为 93 nM 和 469 nM。 GSK319347A 还抑制 IKK2IC50 为 790 nM。

MCE 的所有产品仅用作科学研究,我们不为任何个人用途提供产品和服务

GSK319347A Chemical Structure

GSK319347A Chemical Structure

CAS No. : 862812-98-4

1.  客户无需承担相应的运输费用。

2。  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Price Stock Quantity
5 mg ¥3800 In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All IKK Isoform Specific Products:

  • 生物活性

  • 技术信息

  • 纯度 & 产品资料

  • 参考文献

Description

GSK319347A is a dual inhibitor of TBK1 and IKKε with IC50s of 93 nM and 469 nM, respectively. GSK319347A also inhibits IKK2 with an IC50 of 790 nM.

IC50 & Target

TBK1

93 nM (IC50)

IKK-ε

469 nM (IC50)

IKK2

790 nM (IC50)

In Vitro

GSK319347A (Compound 1) inhibits TBK1 enzyme with an IC50 of 93 nM, which also translates into good cell potency (72 nM). Moreover, IKK-3 Inhibitor exhibits excellent selectivity against cell-cycle kinases CDK2 and AurB[1]. IKK-3 Inhibitor (Compound 13) is a novel IκB kinase 2 (IKK2) inhibitor with an IC50 of 790 nM[2].

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • [1].

    [2].

Molecular Weight

469.53

Formula

C₂₂H₁₉N₃O₅S₂

CAS No.

862812-98-4

SMILES

COC1=CC2=C(C=C1OC)N(C3=CC(OCC4=CC=CC=C4S(=O)(C)=O)=C(C#N)S3)C=N2

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >98.0%

  • [1].

    [2]。

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
GSK319347A
目录号:
HY-14682
需求量:

GSK319347A

Cat。 No。: HY-14682

江苏快3 江苏快3 江苏快3 江苏快3 江苏快3 江苏快三 江苏快3 江苏快三 江苏快3 江苏快三